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Research Training Group (RTG) 1947 “BiOx”

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In aerobic environments life has adapted to reactive oxygen species (ROS) and to reactive nitrogen species (RNS) in various ways, e.g., (i) by developing effective systems to destroy ROS/RNS when they reach harmful levels, (ii) by using ROS/RNS as signal messengers and regulatory effectors, (iii) by using ROS/RNS in immune defence.

In an interdisciplinary and interfaculty approach we aim to overcome the traditional boarders between biochemistry, biophysics, medicine, botany, and pharmacy to analyse the mechanisms of ROS/RNS production and interaction with all constitutents of biological membranes. Therefore the RTG is organized in three intimately linked focus areas with multiple methodological overlap:

  1. Production and membranetargeting of ROS/RNS.
  2. Chemical and physicochemical effects of ROS/RNS on membranes.
  3. (Patho)physiological consequences of ROS/RNS modified membranes.

This interdisciplinary and interfaculty research approach is accompanied by an adequately scheduled teaching program for the trained PHD students.

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