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Our group investigates the androgen receptor as a transcription factor, with clinical relevance in general endocrinology as well as prostate cancer treatments. To this end, we developed crystal structures of AR domains, cell line and mouse models, as well as collections of clinical samples.
This specific project is a collaboration between Frank Claessens, a molecular biologist, and Steven Joniau, a clinical urologist.
Steven Joniau supervises a clinical study called ARNEO to study possible benefits of neoadjuvant treatments for patients with localized, high risk prostate cancer (meaning a 30% change of developing metastases).
Treatments were either androgen deprivation therapy (ADT) or ADT+anti-androgens (apalutamide). We collected serum, urine as well as prostate cancer biopsies (including lymph node metastases) from before and after treatment. Detailed pathological data have been collected. Bulk RNA-seq and bulk ATAC-seq of the biopsies are available. Clinical follow up of patients is > 3 years and increasing.
We are generating spatial and single cell transcriptome data from before and after treatment.
Devos et al. Eur Urol 2023 paper in clinical trial ARNEO
Kiviaho et al. Nat comm 2024 paper on sc and ST of PCa
For more information please contact Prof. dr. Frank Claessens, tel.: +32 16 33 02 53, mail: frank.claessens@kuleuven.be.
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