The Responsive Biomedical Systems Lab (RBSL) at the Department of Health Sciences and Technology (D-HEST) of ETH Zürich is searching for a PhD candidate to join the group to work on the development of protease-responsive ultrasound contrast agents for next generation of point-of-care diagnostics.
Our group focuses on the development of diagnostic and therapeutic systems at the nano-and microscale with the aim to tackle a range of challenging problems in health care. Our research is highly interdisciplinary and combines expertise from the fields of engineering, materials, and nanofabrication with chemistry, synthetic biology, and molecular medicine.
The project will focus on the development of protease-responsive contrast agents for ultrasound imaging. Proteases are critical actors in health and disease that provide insight into the state and progression of inflammatory conditions, cancer, and many other ailments. Detection of their activity could serve as a powerful clinical tool to inform application, monitoring, and adjustment of treatments.
The candidate will work in close collaboration with engineers, biologists, and clinician scientists to develop ultrasound contrast agents for monitoring proteases. Since sonography is a widely available diagnostic technique commonly applied at the point-of-care, this project could build a basis for cost-effective molecular imaging modality. As one concrete clinical application, the project aims to lay the foundation for real-time in vivo assessment of the inflammation state in patients suffering from rheumatoid arthritis. This will be tested in animal models together with clinician scientists.
The ideal candidate for this project should have MSc (or equivalent) in physics, chemistry, chemical engineering or chemistry. Candidates with a biomedical or interdisciplinary background with a strong physics and chemical engineering mindset are also encouraged to apply.
We are looking for a team player with a passion for taking on new challenges. Profound knowledge of standard laboratory techniques (with engineering or biology focus), scientific rigor, and excellent presentation skills round up the profile. The candidate will join an international team of molecular biologists, biochemists, chemical engineers, and material scientists and will be presented with outstanding opportunities for professional and personal development.
We look forward to receiving your online application including the following documents:
Please note that we exclusively accept applications submitted through our online application portal. Applications via email or postal services will not be considered. For additional questions please contact Dr. Matej Vizovisek, by email at firstname.lastname@example.org (no applications).
Earliest Start: 01.02.2021
Latest start: 01.06.2021
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