We are seeking outstanding and highly motivated candidates for a PhD position within the Department of Medicine at the University of Fribourg, Switzerland. The proposed project involves the identification of the role of WNK1/OSR1 signaling pathways in renal proximal tubular endocytosis and/or on renin secretion of granular cells of the kidney. Generated transgenic mouse models WNK1/OSR1 fl/fl*Pax8-rt-TA-LC1-Cre and WNK1/OSR1 fl/fl*renin-rt-TA-LC1-Cre are available in our animal facility.
Techniques include animal experiments, physiological and morphological analysis of newly generated conditional knockout mice models combined with in vitro experimental approaches; cell biology, biochemical methods, molecular biology, and various techniques in morphology using renal tissues. Additionally, cells culture experiments will be included. For methods performed in the laboratory, see attached publications. Experience with mouse work and cell culture is an advantage.
The department of medicine is a dynamic institute with international and interactive groups and with access to world-class facilities. The working languages are English, French and German. The research is done in a collaborative network with leading lab in Fribourg, other labs in Switzerland, and abroad. Projects are funded by the Swiss National Science Foundation. Moreover, Fribourg is a beautiful city located in the heart of Switzerland offering excellent opportunities for cultural and outdoor activities.
Candidates with a Master in Medical Biology, Biochemistry, Physiology or a closely related field may apply. Send applications including a CV, a statement of research interests, transcripts Master and Bachelor studies, and contact details for 2 or more reference letters by e-mail to Prof. Franziska Theilig (firstname.lastname@example.org).
Department of Medicine
Route Albert-Gockel 1
University of Fribourg
- Short-term functional adaptation of aquaporin-1 surface expression in the proximal tubule, a component of glomerulotubular balance. Pohl M, Shan Q, Petsch T, Styp-Rekowska B, Matthey P, Bleich M, Bachmann S, Theilig F. J Am Soc Nephrol. 2015 Jun;26(6):1269-78. doi: 10.1681/ASN.2014020148. PMID: 25270072
- mTOR Regulates Endocytosis and Nutrient Transport in Proximal Tubular Cells. Grahammer F, Ramakrishnan SK, Rinschen MM, Larionov AA, Syed M, Khatib H, Roerden M, Sass JO, Helmstaedter M, Osenberg D, Kühne L, Kretz O, Wanner N, Jouret F, Benzing T, Artunc F, Huber TB, Theilig F. J Am Soc Nephrol. 2016 Jun 13. pii: ASN.2015111224. [Epub ahead of print] PMID: 27297946